Deficiência de vitamina D em pacientes com insuficiência respiratória crônica devido doenças neuromusculares
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USA – 57 pacientes com insuficiência respiratória crônica devido a doenças neuromusculares foram incluídos neste estudo na primeira consulta médica. Setenta e cinco por cento apresentavam níveis baixos de vitamina D. Os níveis variaram dependendo do tipo de dieta empregada. Aqueles que recebiam dieta enteral apresentavam níveis de vitamina D mais elevado. O resumo em inglês pode ser lido abaixo: (JPEN J Parenter Enteral Nutr, Jun 2013) Vitamin D Deficiency in Patients With Neuromuscular Diseases With Chronic Respiratory Failure Sridhar Badireddi, Anita J. Bercher, Jason B. Holder, and Eduardo Mireles-Cabodevila Background: The prevalence and clinical implications of vitamin D deficiency have never been studied in patients with underlying neuromuscular diseases complicated with chronic respiratory failure. The aim of this study is to demonstrate the prevalence of vitamin D deficiency, its relationship with other bone markers, and mode of nutrition. Materials and Methods: Serum 25-hydroxyvitamin D (25[OH]D) levels along with calcium, serum albumin, and phosphorus levels were obtained from 57 patients with chronic respiratory failure due to underlying neuromuscular diseases. These levels were obtained during their first visit to a chronic respiratory diseases clinic. Data with regard to nutrition, respiratory muscle function, and level of mobility were also obtained at the same time. Results: Seventy-five percent of patients had serum 25(OH)D levels ≤30 ng/mL. There is a negative correlation between parathyroid hormone and 25(OH)D levels (P = .006) and corrected calcium levels (P = .066). Serum 25(OH)D levels varied with the mode of nutrition. Patients on enteral nutrition had the highest serum levels of 25(OH)D, whereas combined oral and tube feeds had the lowest 25(OH)D levels (P = .006). Conclusion: Low serum 25(OH)D levels are highly prevalent in patients with neuromuscular disease and chronic respiratory failure. The route of nutrition has an impact on these levels.
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