Distúrbio do sono em crianças com distrofia muscular congênita
França – 20 crianças com distrofia muscular congênita foram submetidas a polisonografia para determinar as alterações do sono. Despertares, diminuição do tempo de sono e redução do sono REM foram observados. Apnéia do sono estava presente em 65% das crianças. O resultado ressalta a importância da polisonografia no acompanhamento de crianças com distrofia muscular congênita.
O resumo em inglês pode ser lido abaixo:
(European Journal of Paediatric Neurology 16 (2012) 619-624) Sleep-disordered breathing in children with congenital muscular dystrophies
Jean-Marc Pinard, Eric Azabou, Nouha Essid, Susana Quijano-Roy, Samir Haddad,Fawzia Cheliout-Héraut
Objective: Most types of neuromuscular diseases are known to be associated with a high risk of sleep-disordered breathing. We performed a prospective study in a well individualized group of muscular disorders, congenital muscular dystrophies (CMD), to characterize the frequency of sleep-disordered breathing and thereby to determine the potential usefulness of sleep studies in such patients.
Methods: Twenty CMD children (12 F, 8 M, aged 4e17 years) were included. Using overnight polysomnography, we determined the following parameters: sleep stages, sleep latency, sleep efficiency index, wake time duration, total sleep time (TST), apnea/hypopnea index (AHI), arterial blood oxygen saturation, and nocturnal paroxysmal EEG activity.
Results: As compared to healthy controls, we detected in our study group frequent awakenings, a decreased TST (mean 448 44.4min) and a decreased REMduration (mean 11.5 3.5% of TST). Significant increase inwake time duration (28e90min) and decrease in REMduration were observed in 12 patients. An apnea/hypopnea syndrome was detected in 13 patients (65%)with central apneas in 8, obstructive apneas in 2 and 3mixed apneas in 3 patients. AHI was >10 in 3 cases, <10> 5 in 4 cases andwere concomitantwith blood oxygen de-saturation in four cases. NPA were detected in 10 patients ranging from10 to 40% of TST.
Interpretation: Our results confirm the high incidence of sleep disordered breathing in children with CMD, and thereby, the usefulness of overnight polysomnography recordings in such patients.
