Peso e altura de crianças com distrofia muscular de Duchenne tratados com prednisona no esquema 10 dias com/10 dias sem
Holanda – os autores compararam o peso e altura das crianças com distrofia muscular de Duchenne sem tratamento com as tratadas com prednisona no esquema 10 dias com/10 dias sem. O número de crianças tratadas foi pequeno mas os resultados permitiram concluir que este regime de tratamento aparentemente não altera o peso e a altura das crianças tratadas.
O resumo em inglês pode ser lido abaixo:
(Neuromuscular Disorders, 2012) Normal height and weight in a series of ambulant Duchenne muscular dystrophy patients using the 10 day on/10 day of prednisone regimen
K. ten Dam, I.J.M. de Groot, C. Noordam, N. van Alfen, J.C.M. Hendriks e L.T.L. Sie – The Netherlands
Prednisone treatment delays the progressive course of Duchenne muscular dystrophy. The aim of this study was to determine the
influence of the 10 day on/10 day of treatment on height and weight. We retrospectively reviewed the growth and weight charts of Duchenne patients born between 1988 and 2006 (patients between 4 and 9 years old, being able to walk in the home situation). Forty-seven patients were eligible for further analysis and divided into two groups: 33 patients treated with prednisone and 14 non-prednisone treated patients. Results of a median follow-up of 57 months (range 27–146) are described. By using linear mixed models this study demonstrates that height and body mass index in prednisone-treated patients with 10/10 regimen are not significantly diferent compared to untreated patients. We cautiously conclude that the alternating prednisone regimen has no apparent side effects on weight and height in the ambulatory phase of Duchenne muscular dystrophy.
